Nephrology Department at Charité – Universitätsmedizin Berlin
The department provides comprehensive expertise across the full spectrum of nephrology, including acute and chronic kidney disease, glomerular disorders, hypertension, electrolyte and acid–base disorders, and all forms of renal replacement therapy such as hemodialysis, peritoneal dialysis, and continuous therapies in intensive care settings. A strong focus on nephrology and intensive care medicine enables the treatment of critically ill patients with complex, multi-organ conditions. The clinic’s special focus is kidney transplantation, especially related and unrelated living donor transplants, including cases of blood group intolerance. Moreover, around 180 to 220 kidney transplants are performed each year. The department is also deeply committed to medical education and training, advancing nephrology through teaching, international collaboration, and high-impact scientific publications.
In nephrology and a kidney department, TBase Data (an advanced Electronic Health Record (EHR) has been continuously recorded for over 20 years. TBase prospectively collects comprehensive patient data, including demographics, diagnoses, medications, laboratory values, clinical notes, radiology and pathology reports, and transplant-specific parameters. This long-term dataset has supported research involving thousands of kidney transplant recipients, with structured, longitudinal records that enable deep clinical phenotyping, outcome analysis, and machine learning applications. The database’s robust architecture, quality validation processes, and integration within Charité’s secure IT infrastructure make it a powerful resource for translational research and precision medicine in nephrology. Furthermore, Charite has also integrated advanced immunogenetic and computational risk-stratification tools into routine clinical research workflows .
For the GEGE4 Nephro Project, Prof.Dr Klemens Budde is serving as project manager. He is a specialist in internal medicine and nephrology and has the additional designation Hypertensioligist DHL. His work encompasses the development and analysis of large-scale longitudinal clinical datasets collected over more than two decades, including structured electronic health record data from several thousand patients in nephrology and kidney transplantation. These data resources support health informatics initiatives, such as telemedicine programs, digital clinical decision support systems, and smart health platforms, that have been implemented and evaluated in routine care settings at Charité.
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